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Your Position: ホーム > DR3 / TNFRSF25

DR3 / TNFRSF25

概要

Name:Tumor necrosis factor receptor superfamily member 25
Target Synonym:Apo-3,Apoptosis-inducing receptor AIR,Apoptosis-mediating receptor DR3,Apoptosis-mediating receptor TRAMP,Death receptor 3,Lymphocyte-associated receptor of death,Protein WSL,DDR3,Death Receptor Beta,TNFRSF12,TRAMP,DR3,WSL-1,PH Domain-Containing Family G Member 5,PLEKHG5,WSL-LR,WSL1,APO3,WSL,TR3,TNF Receptor Superfamily Member 25,Death Domain Receptor 3 Soluble Form,GEF720,Guanine Nucleotide Exchange Factor 720,Apoptosis Inducing Receptor,Tumor Necrosis Factor Receptor Superfamily, Member 25,Ple
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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Synonym Name

TNFRSF25,DR3,APO3,DDR3,TNFRSF12,WSL,WSL1

Background

Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) is also known as Apo-3, Death receptor 3 (DDR3 or DR3), Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor TRAMP, Lymphocyte-associated receptor of death, Apo-3, which is a member of the TNF-receptor superfamily. TNFRSF25 is a homodimer protein, which can Interact strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. TNFRSF25 is receptor for TNFSF12 / APO3L / TWEAK.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
PTX-35 PTX-35 Phase 1 Clinical Heat Biologics Solid tumours Details
PTX-35 PTX-35 Phase 1 Clinical Heat Biologics Solid tumours Details

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